Design and synthesis of C-ring lactone- and lactam-based podophyllotoxin analogues as anticancer agents.
نویسندگان
چکیده
A series of novel podophyllotoxin (PDT) analogues was synthesized in which the lactone moiety was shifted to C ring. Some of the derivatives were also synthesized with modified A ring. Analogues 23 and 25 exhibited potent in vitro cytotoxicity against colon cancer (CaCO(2)) cell line. p-Demethylated E-ring analogues exhibited better potency than the corresponding methylated analogues. These analogues showed toxicity comparable to PDT against human erythrocytes albeit at much higher concentrations (100 microg/ml) than their cytotoxicity values.
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 58 2 شماره
صفحات -
تاریخ انتشار 2010